Italië, 1327. Het christendom is verdeeld door Paus Johannes XXII en keizer Louis IV van het heilige Romeinse Rijk. William van Baskerville komt samen met zijn volgeling Adso von Melk terecht in een afgelegen klooster in de Alpen. Daar worden ze geconfronteerd met een reeks mysterieuze moorden. Terwijl Baskerville en Melk de moorden onderzoeken, worden ze zelf opgejaagd door de genadeloze inquisiteur Bernard Gui, die diegenen vervolgd die kritiek hebben op de paus.
| Writing | Umberto Eco | Novel |
| Editing | Stephen O'Connell | Editor |
| Production | John Turturro | Executive Producer |
| Production | Marco Camilli | Producer |
| Costume & Make-Up | Luigi Rocchetti | Prosthetic Designer |
| Costume & Make-Up | Mauro Tamagnini | Hair Designer |
| Production | Carlo Degli Esposti | Producer |
| Costume & Make-Up | Maurizio Millenotti | Costume Designer |
| Production | Herbert G. Kloiber | Executive Producer |
| Production | Patrizia Massa | Executive Producer |
| Sound | Hubert Westkemper | Sound Designer |
| Costume & Make-Up | Luigi Rocchetti | Makeup Designer |
| Production | Guendalina Ponti | Executive Producer |
| Production | Margherita Murolo | Producer |
| Sound | Thomas Giorgi | Sound Designer |
| Production | Luigi Pinto | Producer |
| Art | Riccardo Monti | Art Direction |
| Production | Marta Aceto | Producer |
| Art | Francesco Frigeri | Production Design |
| Production | Davide Nardini | Producer |
| Production | Michele Zatta | Producer |
| Sound | Francesco Le Metre | Music Editor |
| Production | Matteo Levi | Producer |
| Sound | Gianni Monciotti | Sound Editor |
| Sound | Volker Bertelmann | Original Music Composer |
| Production | Nicola Serra | Producer |
| Production | Lara Manwaring | Casting |
| Writing | Andrea Porporati | Story |
