X-Men, die nog steeds rouwt om de dood van Phoenix (Jean Grey), onderzoekt een zaak van een vermist gemuteerd meisje in Noord-Japan. Dit leidt hen naar een mysterieus virus dat mutanten in monsters verandert. En de U-Men en de Inner Circle willen het virus .
| Visual Effects | Takashi Okazaki | Character Designer |
| Writing | Warren Ellis | Story |
| Production | Jeph Loeb | Executive Producer |
| Production | Alan Fine | Executive Producer |
| Production | Dan Buckley | Executive Producer |
| Production | Eric S. Rollman | Executive Producer |
| Production | Simon Philips | Executive Producer |
| Production | Joe Quesada | Co-Executive Producer |
| Production | Stan Lee | Co-Executive Producer |
| Production | Masao Takiyama | Executive Producer |
| Production | Taro Morishima | Producer |
| Production | Fuminori Hara | Producer |
| Production | Cort Lane | Producer |
| Production | Megan Thomas Bradner | Associate Producer |
