Yakko, Wakko en Dot keren terug voor geheel nieuwe humor en af en toe een epische uitschakeling van gezagsdragers die dringend een egocheck nodig hebben. Starbox en Cindy voegen zich bij de Warners op hun laatste speelafspraak, terwijl de ideeën van Pinky and het Brein voor wereldheerschappij hen naar geheel nieuwe avonturen leiden.
| Production | Peter Hastings | Producer |
| Production | Sherri Stoner | Producer |
| Production | Rusty Mills | Producer |
| Production | Rich Arons | Producer |
| Writing | Tom Ruegger | Characters |
| Production | Greg Emerson | Other |
| Production | Bobbie Page | Production Supervisor |
| Production | Sara Jane Sherman | Casting |
| Art | Roman Laney | Art Direction |
| Production | Clint Lavigne | Executive In Charge Of Production |
| Sound | Tom Ruegger | Main Title Theme Composer |
| Visual Effects | Scott O'Brien | Animation Director |
| Production | Audrey Diehl | Executive In Charge Of Production |
| Sound | Mark Wike | Music Supervisor |
| Production | Joann Estoesta | Producer |
| Sound | Julie Bernstein | Original Music Composer |
| Production | Wellesley Wild | Executive Producer |
| Sound | Steven Bernstein | Original Music Composer |
| Production | Steven Spielberg | Executive Producer |
| Production | Darryl Frank | Executive Producer |
| Production | Gabe Swarr | Co-Executive Producer |
| Production | Sam Register | Executive Producer |
| Production | Justin Falvey | Executive Producer |
